Michael Geusz

Dr. Michael E. Geusz

Ph.D., Vanderbilt University

Office:    414 Life Sciences Building
Phone:    1-419-372-2433
Email:     mgeusz@bgsu.edu

Research:

The role of circadian rhythms in adult neurogenesis, cancer stem cells, and behavior

ResearchGate

michael-geusz

Research Interests:

My lab explores how circadian rhythms in cell physiology and animal behavior impact neurogenesis in the adult brain and multiple types of cancers. We have examined tumor formation and the progression of brain, esophageal, breast, and lung cancers by characterizing cancer stem cells and the epithelial-to-mesenchymal transition that enables cell migration, metastasis, and resistance to cancer therapies. We also explore inhibitory effects of the phytochemical curcumin and related compounds on cancer stem cells and their interactions with the circadian timing system. The laboratory uses live cell imaging and mouse models along with electrophysiology and genomic, proteomic, and bioluminescence imaging techniques. We examine the regulation of circadian clocks by imaging gene expression rhythms in neural explants and other tissues maintained in culture. Ultimately, we are interested in identifying and characterizing the signaling mechanisms acting between the circadian clocks of the body during both normal and disease states.

Updated: 01/07/2025 04:14PM